HPPS Filters

For bacteria removal in aqueous liquids with high particle loads.

  • Cell culture media
  • Sera/plasma
  • Vaccines
  • Diagnostics
  • Buffers
  • Biologicals
  • Ophthalmics
Features and Benefits

PES Dual LayerHPPS is a family of pharmaceutical grade, Polyethersulfone (PES) sterilizing filters. This dual layer filter has an integrated, high capacity prefilter and an asymmetric PES final filter.  

  • Delivers high flow across a wide pH range
  • Low binding characteristics (much lower than cellulose acetate and nylon) for filtering liquids with preservatives and proteins that can adsorb to media
  • Integrated prefilter saves space by eliminating separate prefilter/housing
  • Prefilter extends the life of the final filter
  • Common pore size combinations: 0.2/0.1, 0.5/0.2, 0.8/0.2 microns
Filtration Area
HPPS filtration area
View Data Sheet for further product information:
  • Integrity test specifications
  • Flow rates for all pore sizes
  • Materials of construction
  • Operating parameters
  • Sanitization and sterilization
  • Regulatory & compliance

HPPS Filters

HPPS/HT Filters

HPPS Mini-Capsules


HPPS filters are validated using test procedures that comply with ASTM F 838-15(ae1) protocols for the determination of bacterial retention in filters used for liquid filtration. The challenge level is a minimum of 107 organisms per cm2 of filter media. CPF filters have > 7-log removal when challenged with the organisms listed below (0.03μm, 0.10μm and 0.22μm meet the FDA definition of sterilizing grade filters). Validation Guides are available upon request.

  • 0.03μm: Acholeplasma laidlawii
  • 0.10μm: Brevundimonas diminuta
  • 0.22μm: Brevundimonas diminuta
  • 0.45μm: Serratia marcescens
  • 0.65μm: Saccharomyces cerevisiae
Quality Assurance

HPPS filters are 100% integrity tested. CPF filters are developed and manufactured under an ISO 9001:2015 certified Quality Management System and designed to be used in cGMP-compliant processes. 

HPPS Cartridges 

Available from 5-40 inches in length with several end connections and O-ring options.  For applications using elevated temperatures,  HPPS/HT Cartridges can be used in processes up to 203°F. 

HPPS cartridge        Critical Process Filtration black and white capsule with etched logo 

HPPS Capsules

These filters are HPPS cartridges encapsulated in a polypropylene shell to minimize exposure to process fluids. A popular choice for single-use applications and can be disposed of easily. Sizes range from 2-30 inches in length. HPPS Capsules are available pre-sterilized.

HPPS capsule        Critical process black and white capsule with cutout to show cartridge etched logo 

HPPS Mini-Capsule

Mini-capsules are designed for lab scale testing, process development and small batch production with a filtration area of 500 cm2. HPPS Mini-Capsules are available pre-sterilized. 

HPPS mini-1     Critical Process black and white mini capsule with etched logo 

Why Choose Critical Process Filters?

Quality & Performance
  • Over 20 years of engineering and manufacturing the finest filters for critical applications. 
  • Compliance with industry standards required for your operation
  • Product optimization to meet your performance goals
  • ISO 9001:2015 certified Quality Management System
  • Appropriately rated clean room environment
  • Proven success in pharmaceutical and bioprocessing applications
Price Advantage

It's simple. Our products are very competitively priced. Learn more

Services & Support
  • Presales evaluations/recommendations by highly experienced Application Engineers 
  • Post sales support and trouble shooting
  • Testing & Analysis services (our site or yours)
  • Validation Services

Made in USA 800   90012015Large-(1)

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