SPS Filters

For sterilization of aqueous liquids.

  • Diagnostics
  • SVPs & LVPs
  • Water for Injection
  • Water Purification
  • Buffers
  • Biologicals
  • Vaccines
  • Ophthalmics
Features and Benefits

PES AsymmetricSPS is a family of single layer pharmaceutical grade, Polyethersulfone (PES) sterilizing filters. 


  • Delivers high flow across a wide pH range
  • Low binding characteristics (much lower than cellulose acetate and nylon) for filtering liquids with preservatives and proteins that can adsorb to media
Filtration Area
SPS filtration area
View Data Sheet for further product information:
  • Integrity test specifications
  • Flow rates for all pore sizes
  • Materials of construction
  • Operating parameters
  • Sanitization and sterilization
  • Regulation & compliance

SPS Filters

SPS/HT Filters

SPS Mini-Capsules


SPS filters are validated using test procedures that comply with ASTM F 838-15(ae1) protocols for the determination of bacterial retention in filters used for liquid filtration. The challenge level is a minimum of 107 organisms per cm2 of filter media. CPF filters have > 7-log removal when challenged with the organisms listed below (0.03μm, 0.10μm and 0.22μm meet the FDA definition of sterilizing grade filters). Validation Guides are available upon request.

  • 0.03μm: Acholeplasma laidlawii 
  • 0.10μm: Brevundimonas diminuta
  • 0.22μm: Brevundimonas diminuta
  • 0.45μm: Serratia marcescens
  • 0.65μm: Saccharomyces cerevisiae
Quality Assurance

SPS filters are 100% integrity tested. CPF filters are developed and manufactured under an ISO 9001:2015 certified Quality Management System and designed to be used in cGMP-compliant processes. 

SPS Cartridges 

Available from 5-40 inches in length with several end connections and O-ring options. SPS/HT Cartridges can be used in processes up to 203°F.

SPS cartridge        Critical Process Filtration black and white capsule with etched logo 

SPS Capsules

These filters are SPS cartridges encapsulated in a polypropylene shell to minimize exposure to process fluids. A popular choice for single-use applications and can be disposed of easily. Sizes range from 2-30 inches in length. SPS Capsules are available pre-sterilized.

SPS capsule        Critical process black and white capsule with cutout to show cartridge etched logo 

SPS Mini-Capsule

Mini-capsules are designed for lab scale testing, process development and small batch production with a filtration area of 500 cm2. SPS Mini-Capsules are available pre-sterilized. 

SPS mini     Critical Process black and white mini capsule with etched logo


Why Choose Critical Process Filters?

Quality & Performance
  • Over 20 years of engineering and manufacturing the finest filters for critical applications. 
  • Compliance with industry standards required for your operation
  • Product optimization to meet your performance goals
  • ISO 9001:2015 certified Quality Management System
  • Appropriately rated clean room environment
  • Proven success in pharmaceutical and bioprocessing applications
Price Advantage

It's simple. Our products are very competitively priced. Learn more

Services & Support
  • Presales evaluations/recommendations by highly experienced Application Engineers 
  • Post sales support and trouble shooting
  • Testing & Analysis services (our site or yours)
  • Validation Services

Made in USA 800   90012015Large-(1)

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